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Journal article

Host genetic factors and vaccine-induced immunity to hepatitis B virus infection

Abstract:

Background: Vaccination against hepatitis B virus infection (HBV) is safe and effective; however, vaccine-induced antibody level wanes over time. Peak vaccine-induced anti-HBs level is directly related to antibody decay, as well as risk of infection and persistent carriage despite vaccination. We investigated the role of host genetic factors in long-term immunity against HBV infection based on peak anti-HBs level and seroconversion to anti-HBc. Methods: We analyzed 715 SNP across 133 candida...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.pone.0001898

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Institution:
"London School of Hygiene & Tropical Medicine", "University of Oxford"
Department:
Medical Sciences Division - Clinical Medicine,Nuffield Department of - Human Genetics,Wellcome Trust Centre for Human Genetics
Role:
Author
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Institution:
"London School of Hygiene & Tropical Medicine"
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
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Institution:
"Medical Research Council Laboratories, Banjul, The Gambia"
Role:
Author
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Institution:
"Medical Research Council Laboratories, Banjul, The Gambia"
Role:
Author
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Funding agency for:
Hennig, B
Publisher:
Public Library of Science Publisher's website
Journal:
PLoS ONE Journal website
Volume:
3
Issue:
3
Article number:
e1898
Publication date:
2008-03-01
DOI:
EISSN:
1932-6203
Language:
English
Keywords:
Subjects:
UUID:
uuid:0f3f2087-ecd3-4cf5-ad4d-3262980e7677
Local pid:
ora:2381
Deposit date:
2008-10-10

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