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Tandem-pore K+ channels mediate inhibition of orexin neurons by glucose.

Abstract:

Glucose-inhibited neurons orchestrate behavior and metabolism according to body energy levels, but how glucose inhibits these cells is unknown. We studied glucose inhibition of orexin/hypocretin neurons, which promote wakefulness (their loss causes narcolepsy) and also regulate metabolism and reward. Here we demonstrate that their inhibition by glucose is mediated by ion channels not previously implicated in central or peripheral glucose sensing: tandem-pore K(+) (K(2P)) channels. Importantly...

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Publication status:
Published

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Journal:
Neuron
Volume:
50
Issue:
5
Pages:
711-722
Publication date:
2006-06-01
DOI:
EISSN:
1097-4199
ISSN:
0896-6273
Source identifiers:
314767

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