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Pervasive haplotypic variation in the spliceo-transcriptome of the human major histocompatibility complex.

Abstract:

The human major histocompatibility complex (MHC) on chromosome 6p21 is a paradigm for genomics, showing remarkable polymorphism and striking association with immune and non-immune diseases. The complex genomic landscape of the MHC, notably strong linkage disequilibrium, has made resolving causal variants very challenging. A promising approach is to investigate gene expression levels considered as tractable intermediate phenotypes in mapping complex diseases. However, how transcription varies ...

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Publication status:
Published

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Publisher copy:
10.1101/gr.116681.110

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Journal:
Genome research
Volume:
21
Issue:
7
Pages:
1042-1054
Publication date:
2011-07-01
DOI:
EISSN:
1549-5469
ISSN:
1088-9051
Source identifiers:
140821

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