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Journal article : Correspondence

E. coli Nickel-Iron Hydrogenase 1 catalyses non-native reduction of flavins: demonstration for alkene hydrogenation by old yellow enzyme ene-reductases

Abstract:

A new activity for the [NiFe] uptake hydrogenase 1 of Escherichia coli (Hyd1) is presented. Direct reduction of biological flavin cofactors FMN and FAD is achieved using H2 as a simple, completely atom-economical reductant. The robust nature of Hyd1 is exploited for flavin reduction across a broad range of temperatures (25–70 °C) and extended reaction times. The utility of this system as a simple, easy to implement FMNH2 or FADH2 regenerating system is then demonstrated by supplying reduced f...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1002/anie.202101186

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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Inorganic Chemistry
Oxford college:
Jesus College
Role:
Author
Publisher:
Wiley Publisher's website
Journal:
Angewandte Chemie International Edition Journal website
Volume:
60
Issue:
25
Pages:
13824-13828
Publication date:
2021-05-11
Acceptance date:
2021-03-15
DOI:
EISSN:
1521-3773
ISSN:
1433-7851
Language:
English
Keywords:
Subtype:
Correspondence
Pubs id:
1167930
Local pid:
pubs:1167930
Deposit date:
2021-03-15

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