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Journal article

Reversible energy-transfer switching on a DNA scaffold.

Abstract:
We show that FRET between Pacific Blue (PB) and Alexa488 (A488) covalently attached to a DNA scaffold can be reversibly controlled by photochromic switching of a spiropyran derivative. With the spiropyran in the closed spiro isomeric form, FRET occurs freely between PB and A488. UV-induced isomerization to the open merocyanine form shuts down the FRET process by efficient quenching of the PB excited state. The process is reversed by exposure to visible light, triggering the isomerization to the spiro isomer.
Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1021/ja512416n

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Grant:
sLOLA grant BB/J001694/1 “extending the boundaries of nucleic acid chemistry”
Publisher:
American Chemical Society Publisher's website
Journal:
Journal of the American Chemical Society Journal website
Volume:
137
Issue:
7
Pages:
2444-2447
Publication date:
2015-01-01
DOI:
EISSN:
1520-5126
ISSN:
0002-7863
Source identifiers:
509742
Language:
English
Pubs id:
pubs:509742
UUID:
uuid:116bbb3a-cde8-4e13-bf52-b250dbc2777e
Local pid:
pubs:509742
Deposit date:
2016-03-01

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