Journal article
Rescue of myocardial energetic dysfunction in diabetes through the correction of mitochondrial hyperacetylation by honokiol
- Abstract:
-
Cardiac energetic dysfunction has been reported in patients with type 2 diabetes (T2D) and is an independent predictor of mortality. Identification of the mechanisms driving mitochondrial dysfunction, and therapeutic strategies to rescue these modifications, will improve myocardial energetics in T2D. We demonstrate using 31P-magnetic resonance spectroscopy (31P-MRS) that decreased cardiac ATP and phosphocreatine (PCr) concentrations occurred before contractile dysfunction or a reduction in PC...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Authors
Funding
+ British Heart Foundation
More from this funder
Grant:
FS/10/002/28078
FS/14/17/30634
FS/19/18/34252
Bibliographic Details
- Publisher:
- Journal of Clinical Investigation Publisher's website
- Journal:
- JCI insight Journal website
- Volume:
- 5
- Issue:
- 17
- Article number:
- e140326
- Publication date:
- 2020-09-03
- Acceptance date:
- 2020-07-16
- DOI:
- EISSN:
-
2379-3708
- ISSN:
-
2379-3708
- Pmid:
-
32879143
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
1130742
- Local pid:
- pubs:1130742
- Deposit date:
- 2020-09-07
Terms of use
- Copyright holder:
- Kerr et al.
- Copyright date:
- 2020
- Rights statement:
- © 2020, Kerr et al. This is an open access article published under the terms of the Creative Commons Attribution 4.0 International License.
- Licence:
- CC Attribution (CC BY)
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