Fine mapping genetic determinants of the highly variably expressed MHC gene ZFP57

Journal article

ZFP57 is an important transcriptional regulator involved in DNA methylation and genomic imprinting during development. Here we demonstrate that gene expression also occurs at a low level in adult peripheral blood cells and other tissues including the kidney and thymus, but is critically dependent on underlying local genetic variation within the MHC. We resolve a highly significant expression quantitative trait locus for ZFP57 involving single-nucleotide polymorphisms (SNPs) in the first intro...

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Authors: Plant, K; Fairfax, B; Makino, S; Vandiedonck, C; Radhakrishnan, J

• Publisher: Nature Publishing Group
• Journal: European Journal of Human Genetics
• Volume: 22
• Issue: 4
• Pages: 568-571
• Publication date: 2014-01-01
• DOI: 10.1038/ejhg.2013.244
• EISSN: 1476-5438
• ISSN: 1018-4813
• Language: English
• Keywords: Expression quantitative trait; MHC; Genetic variation; Disease susceptibility; ZFP57