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Fine mapping genetic determinants of the highly variably expressed MHC gene ZFP57

Abstract:

ZFP57 is an important transcriptional regulator involved in DNA methylation and genomic imprinting during development. Here we demonstrate that gene expression also occurs at a low level in adult peripheral blood cells and other tissues including the kidney and thymus, but is critically dependent on underlying local genetic variation within the MHC. We resolve a highly significant expression quantitative trait locus for ZFP57 involving single-nucleotide polymorphisms (SNPs) in the first intro...

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Publisher copy:
10.1038/ejhg.2013.244

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Publisher:
Nature Publishing Group
Journal:
European Journal of Human Genetics
Volume:
22
Issue:
4
Pages:
568-571
Publication date:
2014-01-01
DOI:
EISSN:
1476-5438
ISSN:
1018-4813
Source identifiers:
459873
Language:
English
Keywords:
Pubs id:
pubs:459873
UUID:
uuid:11d544c5-8ef2-4687-88e1-a65d2b3ad108
Local pid:
pubs:459873
Deposit date:
2014-06-16

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