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PHACTR1 modulates vascular compliance but not endothelial function: a translational study

Abstract:

Aims The non-coding locus at 6p24 located in Intron 3 of PHACTR1 has consistently been implicated as a risk allele in myocardial infarction and multiple other vascular diseases. Recent murine studies have identified a role for Phactr1 in the development of atherosclerosis. However, the role of PHACTR1 in vascular tone and in vivo vascular remodelling has yet to be established. The aim of this study was to investigate the role of PHACTR1 in vascular function. Methods and results Prospectively...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1093/cvr/cvac092

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Role:
Author
ORCID:
0000-0003-4208-6802
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Publisher:
Oxford University Press Publisher's website
Journal:
Cardiovascular research Journal website
Article number:
cvac092
Publication date:
2022-06-02
Acceptance date:
2022-05-19
DOI:
EISSN:
1755-3245
ISSN:
0008-6363
Pmid:
35653516
Language:
English
Keywords:
Pubs id:
1262525
Local pid:
pubs:1262525
Deposit date:
2022-07-26

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