Thesis
Expression of S-phase cyclins affects sensitivity to DNA damage response modulators
- Abstract:
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DNA replication stress triggers an intra-S phase checkpoint that is dependent on Ataxia- Telangiectasia and Rad3 related (ATR) kinase signalling. Due to the central role of ATR in the S phase checkpoint, it has been proposed that inhibition of ATR activity could selectively target tumour cells with defects in DNA damage-induced G1 cell cycle checkpoints through accumulation of DNA damage resulting in cell death. However, resistance is a major challenge arising from long-term use of such ki...
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Bibliographic Details
- Type of award:
- MSc by Research
- Level of award:
- Masters
- Awarding institution:
- University of Oxford
Item Description
- UUID:
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uuid:11f5f5bf-2f19-4926-9da7-61a69e344941
- Deposit date:
- 2019-08-14
Terms of use
- Copyright holder:
- Jung, H
- Copyright date:
- 2018
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