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Expression of S-phase cyclins affects sensitivity to DNA damage response modulators

Abstract:

DNA replication stress triggers an intra-S phase checkpoint that is dependent on Ataxia- Telangiectasia and Rad3 related (ATR) kinase signalling. Due to the central role of ATR in the S phase checkpoint, it has been proposed that inhibition of ATR activity could selectively target tumour cells with defects in DNA damage-induced G1 cell cycle checkpoints through accumulation of DNA damage resulting in cell death. However, resistance is a major challenge arising from long-term use of such ki...

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Division:
MSD
Department:
Oncology
Role:
Author

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Role:
Supervisor
Type of award:
MSc by Research
Level of award:
Masters
Awarding institution:
University of Oxford
UUID:
uuid:11f5f5bf-2f19-4926-9da7-61a69e344941
Deposit date:
2019-08-14

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