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Journal article

Development of a non-human primate BCG infection model for the evaluation of candidate tuberculosis vaccines

Abstract:

The lack of validated immunological correlates of protection makes tuberculosis vaccine development difficult and expensive. Using intradermal bacille Calmette-Guréin (BCG) as a surrogate for aerosol Mycobacterium tuberculosis (M.tb) in a controlled human infection model could facilitate vaccine development, but such a model requires preclinical validation. Non-human primates (NHPs) may provide the best model in which to do this. Cynomolgus and rhesus macaques were infected with BCG by intrad...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.tube.2017.11.006

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Jenner Institute
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Jenner Institute
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Jenner Institute
Role:
Author
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Department of Health More from this funder
Wellcome Trust More from this funder
Publisher:
Elsevier Publisher's website
Journal:
Tuberculosis Journal website
Volume:
108
Pages:
99-105
Publication date:
2017-11-15
Acceptance date:
2017-11-14
DOI:
EISSN:
1873-281X
ISSN:
1472-9792
Source identifiers:
745786
Keywords:
Pubs id:
pubs:745786
UUID:
uuid:12051b6a-d06e-4404-b85c-0aeef1db465c
Local pid:
pubs:745786
Deposit date:
2017-11-15

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