Journal article
Development of a non-human primate BCG infection model for the evaluation of candidate tuberculosis vaccines
- Abstract:
-
The lack of validated immunological correlates of protection makes tuberculosis vaccine development difficult and expensive. Using intradermal bacille Calmette-Guréin (BCG) as a surrogate for aerosol Mycobacterium tuberculosis (M.tb) in a controlled human infection model could facilitate vaccine development, but such a model requires preclinical validation. Non-human primates (NHPs) may provide the best model in which to do this. Cynomolgus and rhesus macaques were infected with BCG by intrad...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Authors
Funding
Wellcome Trust
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Department of Health
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Bibliographic Details
- Publisher:
- Elsevier Publisher's website
- Journal:
- Tuberculosis Journal website
- Volume:
- 108
- Pages:
- 99-105
- Publication date:
- 2017-11-15
- Acceptance date:
- 2017-11-14
- DOI:
- EISSN:
-
1873-281X
- ISSN:
-
1472-9792
Item Description
- Keywords:
- Pubs id:
-
pubs:745786
- UUID:
-
uuid:12051b6a-d06e-4404-b85c-0aeef1db465c
- Local pid:
- pubs:745786
- Source identifiers:
-
745786
- Deposit date:
- 2017-11-15
Terms of use
- Copyright holder:
- Harris et al
- Copyright date:
- 2017
- Notes:
- © 2017 The Authors. Published by Elsevier Ltd. Open access funded by Wellcome Trust, available under a Creative Commons Attribution (CC BY 4.0) Licence.
- Licence:
- CC Attribution (CC BY)
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