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Journal article

Age-specific risks, severity, time course, and outcome of bleeding on long-term antiplatelet treatment after vascular events: a population-based cohort study

Abstract:

Background
Lifelong antiplatelet treatment is recommended after ischaemic vascular events, on the basis of trials done mainly in patients younger than 75 years. Upper gastrointestinal bleeding is a serious complication, but had low case fatality in trials of aspirin and is not generally thought to cause long-term disability. Consequently, although co-prescription of proton-pump inhibitors (PPIs) reduces upper gastrointestinal bleeds by 70–90%, uptake is low and guidelines are conflicting...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/S0140-6736(17)30770-5

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Author
Wolfson Foundation More from this funder
Wellcome Trust More from this funder
British Heart Foundation More from this funder
Dunhill Medical Trust More from this funder
National Institute of Health Research More from this funder
Publisher:
Lancet Publisher's website
Journal:
Lancet Journal website
Volume:
390
Issue:
10093
Pages:
490-499
Publication date:
2017-06-13
Acceptance date:
2017-03-10
DOI:
EISSN:
1474-547X
ISSN:
0140-6736
Pubs id:
pubs:700477
UUID:
uuid:121a14c9-fc80-46fe-aa1c-c525cb59d312
Local pid:
pubs:700477
Deposit date:
2017-06-14

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