Thesis
Induction of anti-apoptotic factors by cutaneous Human Papillomaviruses
- Abstract:
-
Human Papillomaviruses (HPVs) are small DNA viruses which specifically infect keratinocytes at different body sites. An association between cutaneous Squamous Cell Carcinoma (SCC) formation, UV irradiation and infection with a high-risk subset of cutaneous HPVs has been postulated although the underlying molecular mechanisms by which HPV may play a role in SCC development are not yet fully elucidated. Expression of the viral E6 oncoprotein has been shown to interfere with DNA damage respons...
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Funding
Bibliographic Details
- Publication date:
- 2010
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
Item Description
- Language:
- English
- Keywords:
- Subjects:
- UUID:
-
uuid:121b0494-9cca-4fee-a800-b54fc36fe43e
- Local pid:
- ora:6188
- Deposit date:
- 2012-04-25
Terms of use
- Copyright holder:
- Tomlins, C
- Copyright date:
- 2010
- Notes:
-
Part of this thesis has been published as: Cutaneous HPV5 E6 causes increased expression of Osteoprotegerin and Interleukin 6 which contribute to evasion of UV-induced apoptosis
Christine Tomlins and Alan Storey
Carcinogenesis (2010) 31 (12): 2155-2164. (http://dx.doi.org/10.1093/carcin/bgq200).
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