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Journal article

Tudor-domain protein PHF20L1 reads lysine methylated retinoblastoma tumour suppressor protein

Abstract:

The retinoblastoma tumour suppressor protein (pRb) classically functions to regulate early cell cycle progression where it acts to enforce a number of checkpoints in response to cellular stress and DNA damage. Methylation at lysine (K) 810, which occurs within a critical CDK phosphorylation site and antagonises a CDK-dependent phosphorylation event at the neighbouring S807 residue, acts to hold pRb in the hypo-phosphorylated growth-suppressing state. This is mediated in part by the recruitmen...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/cdd.2017.135

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Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Target Discovery Institute
Role:
Author
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Publisher:
Springer Nature Publisher's website
Journal:
Cell Death and Differentiation Journal website
Volume:
24
Pages:
139–2149
Publication date:
2017-08-25
Acceptance date:
2017-07-14
DOI:
EISSN:
1476-5403
ISSN:
1350-9047
Pmid:
28841214
Language:
English
Pubs id:
pubs:725920
UUID:
uuid:121bb1f8-cf5c-4800-ab87-5a850fc32244
Local pid:
pubs:725920
Deposit date:
2017-09-14

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