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Thesis

Synthesis of the ABC fragment of pectenotoxin-4

Abstract:

This thesis details the application of two synthetic methodologies, developed by the Donohoe group, to the synthesis of the ABC fragment of pectenotoxin-4, a macrolide marine natural product that consists of 19 stereogenic centres, three tetrahydrofuran rings, one spiroketal and one bicyclic ketal embedded within a 26-membered macrocycle.

Pivotal to the developed synthetic route was the utilisation of an unprecedented cascade osmium catalysed oxidative cyclisation for the constructi...

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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Research group:
Prof. Timothy Donohoe's research group
Oxford college:
Lincoln College
Role:
Author

Contributors

Division:
MPLS
Department:
History Faculty
Sub department:
Archaeology Research Lab
Role:
Supervisor
Publication date:
2012
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
Language:
English
Keywords:
Subjects:
UUID:
uuid:123bf4c1-844a-492a-abdb-f7555719d7ff
Local pid:
ora:7103
Deposit date:
2013-07-25

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