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Comparative life cycle transcriptomics revises Leishmania mexicana genome annotation and links a chromosome duplication with parasitism of vertebrates

Abstract:

Leishmania spp. are protozoan parasites that have two principal life cycle stages: the motile promastigote forms that live in the alimentary tract of the sandfly and the amastigote forms, which are adapted to survive and replicate in the harsh conditions of the phagolysosome of mammalian macrophages. Here, we used Illumina sequencing of poly-A selected RNA to characterise and compare the transcriptomes of L. mexicana promastigotes, axenic amastigotes and intracellular amastigotes. These data ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.ppat.1005186

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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
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Institution:
University of Oxford
Division:
MPLS
Department:
Plant Sciences
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
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Funding agency for:
Fiebig, M
Grant:
092870/Z/10/Z
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Funding agency for:
Kelly, S
Grant:
Leverhulme Trust Early Career Fellowship
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Funding agency for:
Kelly, S
Grant:
Leverhulme Trust Early Career Fellowship
More from this funder
Funding agency for:
Gluenz, E
Grant:
Royal Society University Research Fellow
Publisher:
Public Library of Science Publisher's website
Journal:
PLoS pathogens Journal website
Volume:
11
Issue:
10
Pages:
e1005186
Publication date:
2015-10-01
DOI:
EISSN:
1553-7374
ISSN:
1553-7366
Source identifiers:
579529
Language:
English
Pubs id:
pubs:579529
UUID:
uuid:123e31b6-4af9-4b7c-b9ea-3af829827ff7
Local pid:
pubs:579529
Deposit date:
2016-01-14

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