Journal article
Continuous base identification for single-molecule nanopore DNA sequencing
- Abstract:
-
A single-molecule method for sequencing DNA that does not require fluorescent labelling could reduce costs and increase sequencing speeds. An exonuclease enzyme might be used to cleave individual nucleotide molecules from the DNA, and when coupled to an appropriate detection system, these nucleotides could be identified in the correct order. Here, we show that a protein nanopore with covalently attached adapter molecule can continuously identify unlabelled nucleoside 5'-monophosphate molecule...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Publisher copy:
- 10.1038/NNANO.2009.12
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Authors
Funding
European Commission
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Oxford Nanopore Technologies
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Bibliographic Details
- Publisher:
- Macmillan Publishers Ltd. Publisher's website
- Journal:
- Nature Nanotechnology Journal website
- Volume:
- 4
- Issue:
- 4
- Pages:
- 265-270
- Publication date:
- 2009-04-01
- DOI:
- EISSN:
-
1748-3395
- ISSN:
-
1748-3387
Item Description
- Language:
- English
- Subjects:
- UUID:
-
uuid:124b71ab-f0ee-412a-afd6-436a58e63636
- Local pid:
- ora:4643
- Deposit date:
- 2010-12-16
Related Items
Terms of use
- Copyright holder:
- J Clarke et al
- Copyright date:
- 2009
- Notes:
- Citation: Clarke, J. et al. (2009). 'Continuous base identification for single-molecule nanopore DNA sequencing', Nature Nanotechnology, 4(4), 265-270. [The definitive version of the article is available at http://www.nature.com/nnano/journal/v4/n4/full/nnano.2009.12.html]. The full-text of this article is not available in ORA, but you may be able to access the article via the publisher copy link on this record page.
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