Journal article
The allelic landscape of human blood cell trait variation and links to common complex disease
- Abstract:
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Many common variants have been associated with hematological traits, but identification of causal genes and pathways has proven challenging. We performed a genome-wide association analysis in the UK Biobank and INTERVAL studies, testing 29.5 million genetic variants for association with 36 red cell, white cell, and platelet properties in 173,480 European-ancestry participants. This effort yielded hundreds of low frequency (<5%) and rare (<1%) variants with a strong impact on blood cell ...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 4.0MB)
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- Publisher copy:
- 10.1016/j.cell.2016.10.042
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Authors
Bibliographic Details
- Publisher:
- Cell Press Publisher's website
- Journal:
- Cell Journal website
- Volume:
- 167
- Issue:
- 5
- Pages:
- 1415-1429.e19
- Publication date:
- 2016-11-17
- Acceptance date:
- 2016-10-21
- DOI:
- EISSN:
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1097-4172
- ISSN:
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0092-8674
- Pmid:
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27863252
- Source identifiers:
-
663852
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:663852
- UUID:
-
uuid:1255007c-8fab-4730-8662-79c7e574a9c4
- Local pid:
- pubs:663852
- Deposit date:
- 2017-09-15
Terms of use
- Copyright holder:
- Astle et al
- Copyright date:
- 2016
- Notes:
-
Copyright © 2017 The Authors. Published by Elsevier Inc.
This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
- Licence:
- CC Attribution (CC BY)
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