Journal article
Opioid antagonists and the A118G polymorphism in the μ-opioid receptor gene: effects of GSK1521498 and naltrexone in healthy drinkers stratified by OPRM1 genotype
- Abstract:
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The A118G single-nucleotide polymorphism (SNP rs1799971) in the μ-opioid receptor gene, OPRM1, has been much studied in relation to alcohol use disorders. The reported effects of allelic variation at this SNP on alcohol-related behaviors, and on opioid receptor antagonist treatments, have been inconsistent. We investigated the pharmacogenetic interaction between A118G variation and the effects of two μ-opioid receptor antagonists in a clinical lab setting. Fifty-six overweight and moderate–he...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 429.6KB)
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- Publisher copy:
- 10.1038/npp.2016.60
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Authors
Funding
GlaxoSmithKline (GSK)
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Bibliographic Details
- Publisher:
- Springer Nature Publisher's website
- Journal:
- Neuropsychopharmacology Journal website
- Volume:
- 41
- Issue:
- 11
- Pages:
- 2647-2657
- Publication date:
- 2016-04-25
- Acceptance date:
- 2016-04-06
- DOI:
- EISSN:
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1740-634X
- ISSN:
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0893-133X
- Pmid:
-
27109624
- Source identifiers:
-
1033405
Item Description
- Language:
- English
- Subjects:
- Pubs id:
-
pubs:1033405
- UUID:
-
uuid:125de12b-169a-4fc5-be91-a19e2984a353
- Local pid:
- pubs:1033405
- Deposit date:
- 2019-07-18
Terms of use
- Copyright holder:
- Ziauddeen, H et al
- Copyright date:
- 2016
- Notes:
- © The Authors 2016. This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material.
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