Thesis
Investigating the effect of hypoxia on the JmjC histone lysine demethylase KDM4A
- Abstract:
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The JmjC-histone lysine demethylases (JmjC-KDMs) are epigenetic regulators responsible for the demethylation of methylated lysine residues on the N-terminal histone tails. As Fe2+ and 2-oxoglutarate dependent oxygenases (2OG oxygenases), the JmjC-KDMs possess an absolute requirement for molecular oxygen and are related to the cellular oxygen sensing HIF hydroxylases, PHD2 and FIH. Several JmjC-KDMs are known HIF target genes, hence are upregulated in hypoxia. Moreover, ...
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Authors
Contributors
+ Kawamura, A
Department:
University of Oxford
Role:
Supervisor
+ Flashman, E
Department:
University of Oxford
Role:
Supervisor
+ Schofield, C
Role:
Supervisor
Funding
Bibliographic Details
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
Item Description
- Language:
- English
- Keywords:
- Subjects:
- UUID:
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uuid:125fb1f5-91be-4902-bb8f-7dd5e089b654
- Deposit date:
- 2018-01-24
Related Items
Terms of use
- Copyright holder:
- Hancock, R; . Rebecca L Hancock
- Copyright date:
- 2016
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