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Journal article

Natural variation in Fc glycosylation of HIV-specific antibodies impacts antiviral activity

Abstract:

While the induction of a neutralizing antibody response against HIV remains a daunting goal, data from both natural infection and vaccine-induced immune responses suggest that it may be possible to induce antibodies with enhanced Fc effector activity and improved antiviral control via vaccination. However, the specific features of naturally induced HIV-specific antibodies that allow for the potent recruitment of antiviral activity and the means by which these functions are regulated are poorl...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1172/jci65708

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Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
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Funding agency for:
Ackerman, M
Grant:
P30 AI060354-07
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Funding agency for:
Ercan, A
Grant:
K12 HD51959
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Funding agency for:
Ercan, A
Grant:
K12 HD51959
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Funding agency for:
Choi, I
Grant:
IIS-0905206
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Funding agency for:
Nigrovic, P
Grant:
R21-99435
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Publisher:
American Society for Clinical Investigation Publisher's website
Journal:
Journal of clinical investigation Journal website
Volume:
123
Issue:
5
Pages:
2183-2192
Publication date:
2013-05-01
Acceptance date:
2013-02-07
DOI:
EISSN:
1558-8238
ISSN:
0021-9738
Source identifiers:
405990

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