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Journal article

Mechanisms of Yersinia YopO kinase substrate specificity.

Abstract:

Yersinia bacteria cause a range of human diseases, including yersiniosis, Far East scarlet-like fever and the plague. Yersiniae modulate and evade host immune defences through injection of Yersinia outer proteins (Yops) into phagocytic cells. One of the Yops, YopO (also known as YpkA) obstructs phagocytosis through disrupting actin filament regulation processes - inhibiting polymerization-promoting signaling through sequestration of Rac/Rho family GTPases and by using monomeric actin as bait ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/srep39998

Authors


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Agency for Science, Technology and Research More from this funder
Nanyang Technological University More from this funder
National University of Singapore More from this funder
Publisher:
Nature Publishing Group Publisher's website
Journal:
Scientific Reports Journal website
Volume:
7
Pages:
39998
Publication date:
2017-01-01
Acceptance date:
2016-11-30
DOI:
ISSN:
2045-2322
Source identifiers:
670961
Language:
English
Keywords:
Pubs id:
pubs:670961
UUID:
uuid:12df50c7-a2f9-459f-bbc8-7cbff7d34fb8
Local pid:
pubs:670961
Deposit date:
2017-01-25

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