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Charade of the SR K+-channel: two ion-channels, TRIC-A and TRIC-B, masquerade as a single K+-channel.

Abstract:

The presence of a sarcoplasmic reticulum (SR) K+-selective ion-channel has been known for >30 years yet the molecular identity of this channel has remained a mystery. Recently, an SR trimeric intracellular cation channel (TRIC-A) was identified but it did not exhibit all expected characteristics of the SR K+-channel. We show that a related SR protein, TRIC-B, also behaves as a cation-selective ion-channel. Comparison of the single-channel properties of purified TRIC-A and TRIC-B in symmetr...

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Publication status:
Published

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Publisher copy:
10.1016/j.bpj.2010.04.051

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Journal:
Biophysical journal
Volume:
99
Issue:
2
Pages:
417-426
Publication date:
2010-07-01
DOI:
EISSN:
1542-0086
ISSN:
0006-3495
Source identifiers:
418391
Language:
English
Keywords:
Pubs id:
pubs:418391
UUID:
uuid:12e5fbdd-9d5a-47f1-9a7b-ee1727cc8ae7
Local pid:
pubs:418391
Deposit date:
2013-11-16

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