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Effect of pravastatin on frequency of fracture in the LIPID study: secondary analysis of a randomised controlled trial. Long-term Intervention with Pravastatin in Ischaemic Disease.

Abstract:

BACKGROUND: Statins inhibit the same biochemical pathway as aminobisphosphonates, therefore these cholesterol-lowering agents may have a beneficial effect on osteoporosis. This possibility has been supported by the finding that some statins also stimulate bone formation, and by observational studies suggesting that patients using statins have higher bone densities and lower fracture rates than controls. To assess whether statins have clinically significant effects on bone, we studied the freq...

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Institution:
University of Oxford
Division:
MSD
Department:
Nuffield Department of Population Health
Sub department:
Clinical Trial Service Unit
Role:
Author
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Journal:
Lancet
Volume:
357
Issue:
9255
Pages:
509-512
Publication date:
2001-02-01
DOI:
EISSN:
1474-547X
ISSN:
0140-6736
Source identifiers:
164461
Language:
English
Keywords:
Pubs id:
pubs:164461
UUID:
uuid:1308644a-66d4-4178-a4d9-beda6a5218d5
Local pid:
pubs:164461
Deposit date:
2013-02-20

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