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Thesis

Elucidating the molecular mechanism of TET2 function in hematopoiesis

Abstract:

DNA modifications are epigenetic marks deposited throughout the mammalian genome and play an important role in gene regulation in normal and malignant biological processes. Biological DNA modifications are introduced by DNA methyltransferases (DNMT) and dioxygenases of ten- eleven translocation (TET) family. DNMT proteins can convert cytosine into 5-methylcytosine. TET proteins catalyze the oxidation of 5mC to 5-hydroxymethylcytosine, 5-formylcytosine and 5-carboxylcytosine. These oxidized...

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Oxford Ludwig Institute
Research group:
Skirmantas Kriaucionis
Oxford college:
Magdalen College
Role:
Author

Contributors

Division:
MSD
Department:
NDM
Sub department:
Oxford Ludwig Institute
Role:
Supervisor
ORCID:
0000-0002-2273-5994
More from this funder
Funding agency for:
Kriaucionis, S
Huang, W
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
Keywords:
Subjects:
Deposit date:
2021-05-13

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