Dataset
Lysine Demethylase JMJD2D (KDM4D); A Targeting Enabling Package
- Version:
- 2
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Authors/Creators
Contributors
+ Brennan, P
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Structural Genomics Consortium
Role:
Principal Investigator (PI), Adapter
+ Yapp, C
Role:
Researcher
+ Velupillai, S
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Structural Genomics Consortium
Role:
Researcher
+ Fairhead, M
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Structural Genomics Consortium
Role:
Researcher
+ Hatch, S
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Target Discovery Institute
Role:
Researcher
Expand contributors...
Funding
Bibliographic Details
- Publisher:
- University of Oxford
- Publication date:
- 2018
- Version number:
- 2
Item Description
- Keywords:
- Subjects:
- Documentation:
-
A description of the materials and methods is included within the TEP datasheet. There are 4 members of the Lysine Demethylase JMJD2 (KDM4) family. SGC Oxford has expressed, purified and crystallized the catalytic domains of JMJD2A, JMJD2B, JMJD2C and JMJD2D as part of the probe programme. Fragment screening and X-ray crystallography identified a large number of binders, some of which were progressed into a medicinal chemistry programme. Despite significant effort molecules with probe propert... Expand documentation
- UUID:
-
uuid:1314f1af-8438-4b6e-87f3-6df1a0616b80
- Deposit date:
- 2018-04-20
Related Items
Terms of use
- Copyright date:
- 2018
- Notes:
- This deposition represents version 2 of the TEP datasheet. Changes include, but are not limited to: Addition of hyperlinks throughout the body of the datasheet; Addition of Useful Links to relevant databases; Addition of a Reference box where applicable; Other modifications necessary for page spacing and visualisation. Please note, all data and results within the document remain the same as provided in version 1.
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- ORA Terms and conditions
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