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Journal article

Posttranscriptional regulation of IL-10 gene expression through sequences in the 3'-untranslated region.

Abstract:

IL-10 is an 18-kDa immunoregulatory cytokine the transcription of which is controlled by the ubiquitously expressed transcription factors Sp1 and Sp3. Although many cell types express IL-10 mRNA, not all make detectable amounts of protein, and levels of protein expression vary enormously. We show here that much of this variation can be accounted for by posttranscriptional mechanisms. Multiple copies of potential mRNA destabilizing motifs AUUUA and related sequences can be found to the 3'-untr...

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Publication status:
Published

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Publisher copy:
10.4049/jimmunol.165.1.292

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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
Journal:
Journal of Immunology
Volume:
165
Issue:
1
Pages:
292-296
Publication date:
2000-07-01
DOI:
EISSN:
1550-6606
ISSN:
0022-1767
Source identifiers:
27926

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