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Pathways for glycoprotein degradation in mammalian cells

Abstract:

In mammalian cells, N-glycoproteins comprise the bulk of secretory cargo. N-glycosylation is tightly linked to the mechanisms of co- and post-translational folding and quality control in the endoplasmic reticulum (ER). Aberrant glycoproteins must be cleared from the secretory pathway. Several mechanisms for glycoprotein degradation exist, of which ER-associated degradation (ERAD) is most well-studied. The latter involves retrotranslocation of misfolded glycoproteins into the cytosol, followed...

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Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Research group:
Terry D. Butters
Oxford college:
New College
Role:
Author

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Role:
Supervisor
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Funding agency for:
Kukushkin, N
Publication date:
2011
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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