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The distribution of 5-HT(6) receptors in rat brain: an autoradiographic binding study using the radiolabelled 5-HT(6) receptor antagonist [(125)I]SB-258585.

Abstract:

We used the highly selective 5-HT(6) receptor radioligand [(125)I]SB-258585 (4-iodo-N-[4-methoxy-3-(4-methylpiperazin-1-yl)phenyl]benzene-sulfonamide) to perform autoradiographic binding studies on the rat brain. High levels of specific binding occurred in the corpus striatum, nucleus accumbens, Islands of Calleja and the olfactory tubercle. A high level of binding also appeared in the choroid plexus. Moderate levels occurred in several regions of the hippocampal formation and in certain regi...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
Psychiatry
Role:
Author
Journal:
Brain research
Volume:
934
Issue:
1
Pages:
49-57
Publication date:
2002-04-01
DOI:
EISSN:
1872-6240
ISSN:
0006-8993
Source identifiers:
98117

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