Safety and high level efficacy of the combination malaria vaccine regimen of RTS,S/AS01B with ChAd-MVA vectored vaccines expressing ME-TRAP
Background: The need for a highly efficacious vaccine against Plasmodium falciparum remains pressing. In this controlled human malaria infection (CHMI) study, we assessed the safety, efficacy and immunogenicity of a schedule combining two distinct vaccine types in a staggered immunization regimen: one inducing high-titer antibodies to CSP (RTS,S/AS01B) and the other inducing potent T-cell responses to TRAP using viral vectors.Expand abstract
Method: 37 healthy malaria-naïve adults were vaccinated wit...
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- Peer review status:
- Peer reviewed
- Copyright holder:
- Rampling et al
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© The Authors 2016. This article has been accepted for publication in the Journal of Infectious Diseases. Published by Oxford University Press for the Infectious
Diseases Society of America.
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