Journal article
Safety and high level efficacy of the combination malaria vaccine regimen of RTS,S/AS01B with ChAd-MVA vectored vaccines expressing ME-TRAP
- Abstract:
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Background: The need for a highly efficacious vaccine against Plasmodium falciparum remains pressing. In this controlled human malaria infection (CHMI) study, we assessed the safety, efficacy and immunogenicity of a schedule combining two distinct vaccine types in a staggered immunization regimen: one inducing high-titer antibodies to CSP (RTS,S/AS01B) and the other inducing potent T-cell responses to TRAP using viral vectors.
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Method: 37 healthy malaria-naïve adults were vaccinated wit...
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 876.5KB)
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- Publisher copy:
- 10.1093/infdis/jiw244
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Authors
Funding
National Institute of Health Research
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PATH Malaria Vaccine Initiative
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Bibliographic Details
- Publisher:
- Oxford University Press Publisher's website
- Journal:
- Journal of Infectious Diseases Journal website
- Publication date:
- 2016-01-01
- Acceptance date:
- 2016-06-06
- DOI:
- ISSN:
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1537-6613
- Source identifiers:
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626331
Item Description
Terms of use
- Copyright holder:
- Rampling et al
- Copyright date:
- 2016
- Notes:
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© The Authors 2016. This article has been accepted for publication in the Journal of Infectious Diseases. Published by Oxford University Press for the Infectious
Diseases Society of America.
This is an Open Access article distributed under the terms of the Creative
Commons Attribution License (http://creativecommons.org/licenses/by/4.0/),
which permits unrestricted reuse, distribution, and reproduction in any medium,
provided the original work is properly cited.
- Licence:
- CC Attribution (CC BY)
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