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Thesis

Investigating SAMHD1 restriction of HIV-1 in stem cell-derived macrophages

Abstract:

SAMHD1 is potent in restriction of lentiviruses in primary bone marrow-derived monocytes, macrophages, and dendritic cells and is variably neutralised in these cells by the SIV accessory protein Vpx. However, the dynamics of SAMHD1 restriction of lentiviruses in yolk sac derived tissue-resident macrophages has not been formally demonstrated. Here I use a human stem cell differentiation protocol, competent in the production of macrophages that are developmentally related to, and thus a goo...

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Division:
MSD
Department:
Pathology Dunn School
Role:
Author

Contributors

Role:
Supervisor
ORCID:
0000-0002-2506-1198
Role:
Supervisor
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Programme:
DPhil Project
Funding agency for:
Moore, M
Grant:
W87436H
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
Keywords:
Subjects:
Deposit date:
2020-09-23

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