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Repertoire-wide phylogenetic models of B cell molecular evolution reveal evolutionary signatures of aging and vaccination

Abstract:

In order to produce effective antibodies, B cells undergo rapid somatic hypermutation (SHM) and selection for binding affinity to antigen via a process called affinity maturation. The similarities between this process and evolution by natural selection have led many groups to use phylogenetic methods to characterize the development of immunological memory, vaccination, and other processes that depend on affinity maturation. However, these applications are limited by the fact that most phyloge...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1073/pnas.1906020116

Authors


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Institution:
University of Oxford
Division:
MPLS
Department:
Zoology
Oxford college:
Linacre College
Role:
Author
ORCID:
0000-0002-8797-2667
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Publisher:
National Academy of Sciences Publisher's website
Journal:
Proceedings of the National Academy of Sciences Journal website
Volume:
116
Issue:
45
Pages:
22664-22672
Publication date:
2019-10-21
Acceptance date:
2019-09-22
DOI:
EISSN:
1091-6490
Source identifiers:
1061281
Keywords:
Pubs id:
pubs:1061281
UUID:
uuid:13d79ce4-95ce-4288-9ca3-1ae48146e5e4
Local pid:
pubs:1061281
Deposit date:
2019-10-08

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