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Journal article

Phentolamine block of KATP channels is mediated by Kir6.2.

Abstract:

The ATP-sensitive K+-channel (KATP channel) plays a key role in insulin secretion from pancreatic beta cells. It is closed both by glucose metabolism and the sulfonylurea drugs that are used in the treatment of noninsulin-dependent diabetes mellitus, thereby initiating a membrane depolarization that activates voltage-dependent Ca2+ entry and insulin release. The beta cell KATP channel is a complex of two proteins: Kir6.2 and SUR1. The former is an ATP-sensitive K+-selective pore, whereas SUR1...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.94.21.11716

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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
94
Issue:
21
Pages:
11716-11720
Publication date:
1997-10-01
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
Source identifiers:
114269

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