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Methylazoxymethanol acetate does not fully block cell genesis in the young and aged dentate gyrus.

Abstract:

During adulthood, new neurons are continuously added to the mammalian dentate gyrus (DG). An increasing number of studies have correlated changes in rates of dentate neurogenesis with memory abilities. One study based on subchronic treatment with the toxin methylazoxymethanol acetate (MAM) has provided causal evidence that neurogenesis is involved in hippocampal-dependent trace conditioning. In contrast, spatial learning is not impaired following MAM treatment. We hypothesized that this was d...

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Institution:
University of Oxford
Division:
MSD
Department:
Pharmacology
Role:
Author
Journal:
European journal of neuroscience
Volume:
22
Issue:
3
Pages:
778-783
Publication date:
2005-08-01
DOI:
EISSN:
1460-9568
ISSN:
0953-816X
Source identifiers:
329233

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