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Thesis

Structural and biochemical studies of cysteine-rich domains in morphogen signalling

Abstract:

Cell-to-cell communication is vital to the morphogenesis and homeostasis of multicellular organisms and is linked to a variety of diseases. Extracellular Cysteine-Rich Domains (CRDs) are involved in the control of fundamental signalling pathways, mediating crucial interactions with protein and small molecule ligands. The localisation of extracellular ligands and receptors is regulated by the cell surface glycosaminoglycan (GAG) layer. In this thesis, structural and biochemical methods have...

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Division:
MSD
Department:
Doctoral Training Centre - MSD
Role:
Author

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Role:
Supervisor
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
UUID:
uuid:141d7cde-51ed-4d71-9d8b-2a3b5a5338b0
Deposit date:
2017-05-17

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