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Thesis

The characterisation of intestinal dendritic cells and the control of immune responses towards the microbiota

Abstract:

Dendritic cells (DCs) are regulators of the immune response and are thought to be critical in maintaining tolerance towards the intestinal microbiota. Recent data have identified distinct subsets of DCs with specific functional properties. The objective of this thesis was to further define CD103⁺ and CX3CR1⁺ DCs in the intestine and to determine how DCs and regulatory T (Treg) cell responses are influenced by the microbiota.

Using multicolour flow cytometry, we identified two CD103⁺ ...

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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Research group:
Powrie Lab, Translational Gastroenterology Unit
Oxford college:
Lincoln College
Role:
Author

Contributors

Division:
MSD
Department:
Pathology Dunn School
Role:
Supervisor
Publication date:
2011
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
Keywords:
Subjects:
UUID:
uuid:14284c3c-1aa4-4125-ad31-e74ded4e75bc
Local pid:
ora:11659
Deposit date:
2015-06-12

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