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Tau phosphorylation sites work in concert to promote neurotoxicity in vivo.

Abstract:

Tau is a microtubule binding protein implicated in a number of human neurodegenerative disorders, including Alzheimer's disease. Phosphorylation of serine-proline/threonine-proline sites, targeted by proline-directed kinases, coincides temporally with neurodegeneration in the human diseases. Recently, we demonstrated that this unique group of serines and threonines has a critical role in controlling tau toxicity in a Drosophila model of tauopathy. Here, we use a combination of genetic and bio...

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Publisher copy:
10.1091/mbc.e07-04-0327

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
Weatherall Insti. of Molecular Medicine
Role:
Author
Journal:
Molecular biology of the cell
Volume:
18
Issue:
12
Pages:
5060-5068
Publication date:
2007-12-01
DOI:
EISSN:
1939-4586
ISSN:
1059-1524
Source identifiers:
256182
Language:
English
Keywords:
Pubs id:
pubs:256182
UUID:
uuid:142f0fc4-89b7-4dc4-8c32-a58cd90e9d84
Local pid:
pubs:256182
Deposit date:
2012-12-19

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