Developmental hematopoiesis: ontogeny, genetic programming and conservation.
Hematopoietic stem cells (HSCs) sustain blood production throughout life and are of pivotal importance in regenerative medicine. Although HSC generation from pluripotent stem cells would resolve their shortage for clinical applications, this has not yet been achieved mainly because of the poor mechanistic understanding of their programming. Bone marrow HSCs are first created during embryogenesis in the dorsal aorta (DA) of the midgestation conceptus, from where they migrate to the fetal liver...Expand abstract
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- Peer reviewed
(Accepted manuscript, pdf, 1.2MB)
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- International Society for Experimental Hematology
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© 2014 ISEH - International Society for Experimental Hematology.
Published by Elsevier Inc This is the accepted manuscript version of the article. The final version is available online from Elsevier at: [10.1016/j.exphem.2014.06.001]
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