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Journal article

Developmental hematopoiesis: ontogeny, genetic programming and conservation.

Abstract:

Hematopoietic stem cells (HSCs) sustain blood production throughout life and are of pivotal importance in regenerative medicine. Although HSC generation from pluripotent stem cells would resolve their shortage for clinical applications, this has not yet been achieved mainly because of the poor mechanistic understanding of their programming. Bone marrow HSCs are first created during embryogenesis in the dorsal aorta (DA) of the midgestation conceptus, from where they migrate to the fetal liver...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.exphem.2014.06.001

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
Weatherall Insti. of Molecular Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
Weatherall Insti. of Molecular Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
Weatherall Insti. of Molecular Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
Weatherall Insti. of Molecular Medicine
Role:
Author
Oxford BHF Centre of Research Excellence More from this funder
Publisher:
Elsevier Publisher's website
Journal:
Experimental Hematology Journal website
Volume:
42
Issue:
8
Pages:
669-683
Publication date:
2014-06-17
Acceptance date:
2014-06-09
DOI:
EISSN:
1873-2399
ISSN:
0301-472X
Source identifiers:
471049
Language:
English
Keywords:
Pubs id:
pubs:471049
UUID:
uuid:143fc50d-4dd4-47e4-afcd-907018a7636e
Local pid:
pubs:471049
Deposit date:
2014-12-19

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