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Quantifying individual noxious-evoked baseline sensitivity to optimise analgesic trials in neonates

Abstract:

Despite the high burden of pain experienced by hospitalised neonates, there are few analgesics with proven efficacy. Testing analgesics in neonates is experimentally and ethically challenging and minimising the number of neonates required to demonstrate efficacy is essential. EEG (electroencephalography)-derived measures of noxious-evoked brain activity can be used to assess analgesic efficacy; however, as variability exists in neonate’s responses to painful procedures, large sample sizes are...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.7554/elife.65266

Authors


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Role:
Author
ORCID:
0000-0002-3961-1568
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Institution:
University of Oxford
Division:
MSD
Sub department:
Paediatrics
Role:
Author
ORCID:
0000-0002-7981-0836
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Role:
Author
ORCID:
0000-0002-4408-167X
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Publisher:
eLife Sciences Publications Publisher's website
Journal:
eLife Journal website
Volume:
10
Article number:
e65266
Publication date:
2021-04-13
Acceptance date:
2021-03-17
DOI:
EISSN:
2050-084X
Pmid:
33847561
Language:
English
Keywords:
Pubs id:
1171611
Local pid:
pubs:1171611
Deposit date:
2021-05-05

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