Journal article
A critical epithelial survival axis regulated by MCL-1 maintains thymic function in mice
- Abstract:
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T cell differentiation is governed by interactions with thymic epithelial cells (TECs) and defects in this process undermine immune function and tolerance. To uncover new strategies to restore thymic function and adaptive immunity in immunodeficiency, we sought to determine the molecular mechanisms that control life and death decisions in TEC. Guided by gene expression profiling, we created mouse models which specifically deleted pro-survival genes in TEC. We found that while BCL-2 and BCL-XL...
Expand abstract
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Accepted manuscript, pdf, 2.4MB)
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- Publisher copy:
- 10.1182/blood-2017-03-771576
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Authors
Funding
+ Australian National Health and Medical Research Council
More from this funder
Grant:
Career Development Fellowship-
2 1090236, 1016701
Senior Principal Research Fellowship 1020363
GNT0637353, GNT1049724, GNT1121325
Australia Fellowship
GNT 1054618
GNT1086727
1058892
+ Leukemia and Lymphoma Society of America
More from this funder
Grant:
Specialized Center of Research [SCOR] grant. 7001-13
Bibliographic Details
- Publisher:
- American Society of Hematology Publisher's website
- Journal:
- Blood Journal website
- Volume:
- 130
- Issue:
- 23
- Pages:
- 2504-2515
- Publication date:
- 2017-09-29
- Acceptance date:
- 2017-09-22
- DOI:
- EISSN:
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1528-0020
- ISSN:
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0006-4971
- Source identifiers:
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731406
Item Description
- Pubs id:
-
pubs:731406
- UUID:
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uuid:14516543-6139-47f6-bae9-4ec1baac91bc
- Local pid:
- pubs:731406
- Deposit date:
- 2017-10-02
Terms of use
- Copyright holder:
- American Society of Hematology
- Copyright date:
- 2017
- Notes:
- Copyright © 2017 American Society of Hematology. This is the accepted manuscript version of the article. The final version is available online from the American Society of Hematology at: https://doi.org/10.1182/blood-2017-03-771576
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