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Journal article

A critical epithelial survival axis regulated by MCL-1 maintains thymic function in mice

Abstract:

T cell differentiation is governed by interactions with thymic epithelial cells (TECs) and defects in this process undermine immune function and tolerance. To uncover new strategies to restore thymic function and adaptive immunity in immunodeficiency, we sought to determine the molecular mechanisms that control life and death decisions in TEC. Guided by gene expression profiling, we created mouse models which specifically deleted pro-survival genes in TEC. We found that while BCL-2 and BCL-XL...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1182/blood-2017-03-771576

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Grant:
Career Development Fellowship- 2 1090236, 1016701
Senior Principal Research Fellowship 1020363
GNT0637353, GNT1049724, GNT1121325
Australia Fellowship
GNT 1054618
GNT1086727
1058892
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Grant:
Specialized Center of Research [SCOR] grant. 7001-13
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Grant:
LeukaemiaResearchFoundation
MIRS
MIFRS
Publisher:
American Society of Hematology Publisher's website
Journal:
Blood Journal website
Volume:
130
Issue:
23
Pages:
2504-2515
Publication date:
2017-09-29
Acceptance date:
2017-09-22
DOI:
EISSN:
1528-0020
ISSN:
0006-4971
Source identifiers:
731406
Pubs id:
pubs:731406
UUID:
uuid:14516543-6139-47f6-bae9-4ec1baac91bc
Local pid:
pubs:731406
Deposit date:
2017-10-02

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