Journal article
Metabolomic profiling in acute ST‐segment–elevation myocardial infarction identifies succinate as an early marker of human ischemia–reperfusion injury
- Abstract:
-
Background Ischemia–reperfusion injury following ST‐segment–elevation myocardial infarction (STEMI) is a leading determinant of clinical outcome. In experimental models of myocardial ischemia, succinate accumulation leading to mitochondrial dysfunction is a major cause of ischemia–reperfusion injury; however, the potential importance and specificity of myocardial succinate accumulation in human STEMI is unknown. We sought to identify the metabolites released from the heart in... Expand abstract
- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Access Document
- Files:
-
-
(Version of record, pdf, 601.4KB)
-
- Publisher copy:
- 10.1161/JAHA.117.007546
Why is the content I wish to access not available via ORA?
Bibliographic data (the information relating to research outputs) and full-text items (e.g. articles, theses, reports, etc.) arrive in ORA from several different sources. Unfortunately we are not able to make available the full-text for every research output.
Please contact the ORA team (
) if you have queries regarding unavailable content OR if you are aware of a full-text copy we can make available.
) if you have queries regarding unavailable content OR if you are aware of a full-text copy we can make available.
Content may be unavailable for the following four reasons
-
Version unsuitable
-
We have not obtained a suitable full-text for a given research output. See this page for more information.
-
Recently completed
-
Sometimes content is held in ORA but is unavailable for a fixed period of time to comply with the policies and wishes of rights holders.
-
Permissions
-
All content made available in ORA should comply with relevant rights, such as copyright. See this page for more information.
-
Clearance
-
Some thesis volumes scanned as part of the digitisation scheme funded by Dr Leonard Polonsky are currently unavailable due to sensitive material or uncleared third-party copyright content. We are attempting to contact authors whose theses are affected.
Alternative access to the full-text
You may be able to access the full-text directly from the publisher's website using the 'Publisher Copy' link in the 'Links & Downloads' box from a research output's ORA record page. This method may require an institutional or individual subscription to the journal/resource.
Authors
Funding
+ British Heart
Foundation Oxford Centre of Research Excellence
More from this funder
Grant:
RG/13/
1/30181
NIHR Oxford Biomedical
Research Centre
More from this funder
Bibliographic Details
- Publisher:
- American Heart Association Publisher's website
- Journal:
- Journal of the American Heart Association Journal website
- Volume:
- 7
- Issue:
- 8
- Article number:
- e007546
- Publication date:
- 2018-04-06
- Acceptance date:
- 2018-02-26
- DOI:
- ISSN:
-
2047-9980
- Pmid:
-
29626151
- Source identifiers:
-
835417
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:835417
- UUID:
-
uuid:147f3a90-432b-41be-99d6-530206ad01f6
- Local pid:
- pubs:835417
- Deposit date:
- 2018-09-04
Terms of use
- Copyright holder:
- Kohlhauer et al
- Copyright date:
- 2018
- Notes:
-
Copyright © 2018 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley. This is an open access article under the terms of the Creative Commons
Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is noncommercial
and no modifications or adaptations are made.
If you are the owner of this record, you can report an update to it here: Report update to this record