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Journal article

Transgenic overexpression of the type I isoform of neuregulin 1 affects working memory and hippocampal oscillations but not long-term potentiation.

Abstract:

Neuregulin 1 (NRG1) is a growth factor involved in neurodevelopment and plasticity. It is a schizophrenia candidate gene, and hippocampal expression of the NRG1 type I isoform is increased in the disorder. We have studied transgenic mice overexpressing NRG1 type I (NRG1(tg-type I)) and their wild-type littermates and measured hippocampal electrophysiological and behavioral phenotypes. Young NRG1(tg-type I) mice showed normal memory performance, but in older NRG1(tg-type I) mice, hippocampus-d...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1093/cercor/bhr223

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Institution:
University of Oxford
Division:
MSD
Department:
Psychiatry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pharmacology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Psychiatry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Psychiatry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pharmacology
Role:
Author
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Funding agency for:
Deakin, I
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Funding agency for:
Harrison, P
Publisher:
Oxford University Press Publisher's website
Journal:
Cerebral cortex (New York, N.Y. : 1991) Journal website
Volume:
22
Issue:
7
Pages:
1520-1529
Publication date:
2012-07-01
DOI:
EISSN:
1460-2199
ISSN:
1047-3211
Source identifiers:
172131
Language:
English
Keywords:
UUID:
uuid:14a5f585-378e-4d4a-9483-8ae4d9901269
Local pid:
pubs:172131
Deposit date:
2012-12-19

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