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LRRK2 interacts with the vacuolar-type H+-ATPase pump a1 subunit to regulate lysosomal function

Abstract:

Lysosomal dysfunction lies at the centre of the cellular mechanisms underlying Parkinson's disease although the precise underlying mechanisms remain unknown. We investigated the role of leucine rich repeat kinase 2 (LRRK2) on lysosome biology and the autophagy pathway in primary neurons expressing the human LRRK2-G2019S or LRKK2-R1441C mutant, or the human wild-type (hWT-LRRK2) genomic locus. The expression of LRRK2-G2019S or hWT-LRRK2 inhibited autophagosome production, whereas LRRK2-R1441C ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Files:
Publisher copy:
10.1093/hmg/ddz088

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
ORCID:
0000-0001-8350-6928
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Physiology Anatomy and Genetics
Oxford college:
Christ Church
Role:
Author
Publisher:
Oxford University Press Publisher's website
Journal:
Human Molecular Genetics Journal website
Volume:
28
Issue:
16
Pages:
2696–2710
Publication date:
2019-04-30
Acceptance date:
2019-04-15
DOI:
EISSN:
1460-2083
ISSN:
0964-6906
Pmid:
31039583
Source identifiers:
996048
Language:
English
Pubs id:
pubs:996048
UUID:
uuid:14bb1522-db45-4280-ad08-20db18555ff3
Local pid:
pubs:996048
Deposit date:
2019-07-02

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