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Fully automated radiosynthesis of N1-[18F]fluoroethyl-tryptophan and study of its biological activity as a new potential substrate for indoleamine 2,3-dioxygenase PET imaging

Abstract:

Introduction Indoleamine 2,3-dioxygenase (IDO) catalyzes the initial step in the catabolism of l-tryptophan along the kynurenine pathway and exerts immunosuppressive properties in inflammatory and tumor tissues by blocking locally T-lymphocyte proliferation. Recently, 1-(2-[19F]fluoroethyl)-dl-tryptophan (1-[19F]FE-dl-Trp) was reported as a good and specific substrate of this enzyme. Herein, the radiosynthesis of its radioactive isotopomer (1-[18F]FE-dl-Trp, dl-[18F]5) is presented along with...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.nucmedbio.2016.03.001

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Oxford Ludwig Institute
Role:
Author
ORCID:
0000-0002-4995-3270
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Publisher:
Elsevier Publisher's website
Journal:
Nuclear Medicine and Biology Journal website
Volume:
43
Issue:
6
Pages:
379-389
Publication date:
2016-03-11
Acceptance date:
2016-03-07
DOI:
EISSN:
1872-9614
ISSN:
0969-8051
Pmid:
27260779
Source identifiers:
809049
Language:
English
Keywords:
Pubs id:
pubs:809049
UUID:
uuid:14be154d-fc89-4f77-96c9-8f1cd16e213b
Local pid:
pubs:809049
Deposit date:
2017-12-11

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