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Thesis

Mechanisms of induction and modulation of the pro-inflammatory cytokine interleukin-1beta

Abstract:

Interleukin (IL)-1beta is a powerful pro-inflammatory cytokine with important roles in directing both innate and adaptive immunity. As a result, its production is tightly controlled, with the synthesis of an inactive form (pro-IL-1beta) and the requirement of a second signal. This induces the formation of the inflammasome, a macromolecular complex which mediates the maturation of IL-1beta into the bioactive cytokine. Given its significance, it is important to identify mechanisms of IL-1...

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  • (Dissemination version, pdf, 5.3MB)

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Research group:
Cerundolo
Oxford college:
Brasenose College
Role:
Author

Contributors

Division:
MSD
Department:
NDM
Role:
Supervisor
More from this funder
Funding agency for:
Yip, RHN
Grant:
086322/Z/08/Z
Publication date:
2012
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
Keywords:
Subjects:
UUID:
uuid:14e4bd37-d3f3-4419-b2f0-564c22df4d09
Local pid:
ora:6839
Deposit date:
2013-05-03

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