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Journal article

Cellular internalisation of an inositol phosphate visualised by using fluorescent InsP5

Abstract:

When applied extracellularly, myo-inositol hexakisphosphate (InsP 6) and myo-inositol pentakisphosphate (InsP5) can inhibit the growth and proliferation of tumour cells. There is debate about whether these effects result from interactions of InsP6 and InsP5 with intracellular or extracellular targets. We synthesised FAM-InsP 5, a fluorescent conjugate of InsP5 that allows direct visualisation of its interaction with cells. FAM-InsP5 was internalised by H1229 tumour cells, a finding that suppo...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1002/cbic.201300583

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Pharmacology
Role:
Author
Wellcome Trust More from this funder
Publisher:
Wiley Publisher's website
Journal:
ChemBioChem Journal website
Volume:
15
Issue:
1
Pages:
57–67
Publication date:
2013-12-06
DOI:
ISSN:
1439-7633 and 1439-4227
Pmid:
24311195
Language:
English
Keywords:
Pubs id:
pubs:640292
UUID:
uuid:151199ee-be74-4da8-a10f-2a92d15c049e
Local pid:
pubs:640292
Deposit date:
2016-08-23

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