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Malaria protection due to sickle haemoglobin depends on parasite genotype

Abstract:

Host genetic factors can confer resistance against malaria, raising the question of whether this has led to evolutionary adaptation of parasite populations. Here we searched for association between candidate host and parasite genetic variants in 3,346 Gambian and Kenyan children with severe malaria caused by Plasmodium falciparum. We identified a strong association between sickle haemoglobin (HbS) in the host and three regions of the parasite genome, which is not explained by population struc...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41586-021-04288-3

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
ORCID:
0000-0002-1710-9024
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Role:
Author
ORCID:
0000-0002-1614-9366
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Publisher:
Springer Nature Publisher's website
Journal:
Nature Journal website
Volume:
602
Issue:
7895
Pages:
106-111
Publication date:
2021-12-09
Acceptance date:
2021-11-29
DOI:
EISSN:
1476-4687
ISSN:
0028-0836
Pmid:
34883497
Language:
English
Keywords:
Pubs id:
1226058
Local pid:
pubs:1226058
Deposit date:
2022-07-20

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