Journal article icon

Journal article

Site-directed mutagenesis of the CC chemokine binding protein 35K-Fc reveals residues essential for activity and mutations that increase the potency of CC chemokine blockade.

Abstract:

Chemokines of the CC class are key mediators of monocyte recruitment and macrophage differentiation and have a well documented role in many inflammatory diseases. Blockade of chemokine activity is therefore an attractive target for anti-inflammatory therapy. 35K (vCCI) is a high-affinity chemokine binding protein expressed by poxviruses, which binds all human and murine CC chemokines, preventing their interaction with chemokine receptors. We developed an Fc-fusion protein of 35K with a modifi...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1124/mol.111.071985

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM Cardiovascular Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
Journal:
Molecular pharmacology
Volume:
80
Issue:
2
Pages:
328-336
Publication date:
2011-08-01
DOI:
EISSN:
1521-0111
ISSN:
0026-895X
Source identifiers:
141244
Language:
English
Keywords:
Pubs id:
pubs:141244
UUID:
uuid:15ba937a-3ba2-4964-aa4f-aceebf33d64e
Local pid:
pubs:141244
Deposit date:
2012-12-19

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP