Journal article icon

Journal article

Activation of glycogen phosphorylase and glycogenolysis in rat skeletal muscle by AICAR — an activator of AMP-activated protein kinase

Abstract:

We determined whether the cell permeable molecule AICAR, whose metabolite activates AMP-activated protein kinase (AMPK) in cells, affected glycogen metabolism in rat seleus muscle preparations in vitro. The basal and insulin-stimulated rates of radiochemical lactate formation, net lactate release and glycogen synthesis were determined. AICAR stimulated net lactate release (but not radiochemical lactate formation) only at a basal concentration of insulin. An increased rate of glycogenolysis...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Files:
Publisher copy:
10.1016/0014-5793(96)00129-9

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author

Contributors

Zeneca Pharmaceuticals More from this funder
British Heart Foundation More from this funder
Medical Research Council More from this funder
Publisher:
Elsevier Publisher's website
Journal:
FEBS Letters Journal website
Volume:
382
Issue:
1-2
Pages:
43-47
Publication date:
1996-03-01
DOI:
EISSN:
9600-1299
ISSN:
0014-5793
Language:
English
Keywords:
Subjects:
UUID:
uuid:1616cd97-6eea-411c-ac17-ad4899fed69e
Local pid:
ora:8523
Deposit date:
2014-06-05

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP