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Thesis

Structure and function of trimeric intracellular cation channels (TRIC) and ryanodine receptors (RyR)

Abstract:

Controlled Ca2+-release from the sarcoplasmic reticulum (SR) during excitation-contraction coupling (EC-coupling) is essential for cardiac and skeletal muscle contraction. Ca2+ is released through ryanodine receptors (RyR) in the SR membrane but there are other, different types of ion channels in the SR with unclear physiological roles, and some of these channels have not been identified. In this thesis, I have investigated the structural and biophysical properties of...

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Institution:
University of Oxford
Division:
MSD
Department:
Pharmacology
Sub department:
Pharmacology
Research group:
Professor Rebecca Sitsapesan
Oxford college:
Linacre College
Role:
Author

Contributors

Role:
Contributor
Role:
Supervisor
Institution:
University of Oxford
Division:
MSD
Department:
Pharmacology
Sub department:
Pharmacology
Role:
Supervisor
Division:
MSD
Department:
Pharmacology
Sub department:
Pharmacology
Role:
Supervisor
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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