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Thesis

Autophagy’s roles in the activation and ageing of CD4+ T cells

Abstract:

Autophagy plays an essential role in the differentiation, homeostasis and renewal of various cell types. Though its molecular machinery has been extensively elucidated, what autophagy specifically degrades remains largely unclear. Here, we created the Lc3b-APEX2 transgenic mouse model based on the proximity biotinylation technique, which, for the first time, enables us to directly map the proteinaceous content of autophagosomes in any primary cell. Through inserting APEX2, an engineered as...

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Division:
MSD
Department:
NDORMS
Role:
Author

Contributors

Role:
Supervisor
Role:
Supervisor
Role:
Examiner
Role:
Examiner
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
Keywords:
Subjects:
Deposit date:
2022-05-19

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